Recent publications

Stavenuiter F. Factor Seven Activating Protease: in Search of a Physiological Role. Utrecht, Utrecht University, June 23, 2010;

van Helden PM, Kaijen PH, Mauser-Bunschoten EP, Fischer K, van den Berg HM, Voorberg J. Domain specificity of factor VIII inhibitors during immune tolerance induction in patients with haemophilia A. Haemophilia 2010; :epub ahead of print. abstract

van Helden PM, van Haren SD, Fijnvandraat K, van den Berg HM, Voorberg J. Factor VIII-specific B cell responses in haemophilia A patients with inhibitors. Haemophilia 2010; 16(102):35-43. abstract

Pos W, Crawley JT, Fijnheer R, Voorberg J, Lane DA, Luken BM. An autoantibody epitope comprising residues R660, Y661 and Y665 in the ADAMTS13 spacer domain identifies a binding site for the A2 domain of VWF. Blood 2010; 115(8):1640-1649. abstract

Pos W, Luken BM, Kremer Hovinga JA, Turenhout EA, Scheiflinger F, Dong JF, Fijnheer R, Voorberg J. VH1-69 germline encoded antibodies directed towards ADAMTS13 in patients with acquired TTP. J Thromb Haemost 2009; 7 (3):421-428. abstract

Bridges DJ, Bunn J, van Mourik JA, Grau G, Preston RJ, Molyneux M, Combes V, O'Donnell JS, De Laat B, Craig A. Rapid activation of endothelial cells enables P. falciparum adhesion to platelet decorated von Willebrand factor strings. Blood 2010; 115, No. 7, pp. 1472-1474(7):1472-1474. abstract

De Laat B, Pengo V, Pabinger I, Musial J, Voskuyl AE, Bultink IE, Ruffatti A, Rozman B, Kveder T, de Moerloose P, Boehlen F, Rand J, Ulcova-Gallova Z, Mertens K, de Groot PG. The association between circulating antibodies against domain I of beta2-glycoprotein I and thrombosis: an international multicenter study. J Thromb Haemost 2009; 7(11):1767-1773. abstract

De Laat B, de Groot PG, Derksen RH, Urbanus RT, Mertens K, Rosendaal FR, Doggen CJ. Association between beta2-glycoprotein I plasma levels and the risk of myocardial infarction in older men. Blood 2009; 114(17):3656-3661. abstract

De Laat B, de Groot PG, Derksen RH, Urbanus RT, Mertens K, Rosendaal FR, Doggen CJ. Association between beta2-glycoprotein I plasma levels and the risk of myocardial infarction in older men. Blood 2009; 114 (17):3656-3661. abstract

Meems H, Meijer AB, Cullinan DB, Mertens K, Gilbert GE. Factor VIII C1 domain residues Lys 2092 and Phe 2093 contribute to membrane binding and cofactor activity. Blood 2009; 114(18):3938-3946. abstract

Meems H, Meijer AB, Cullinan DB, Mertens K, Gilbert GE. Factor VIII C1 domain residues Lys 2092 and Phe 2093 contribute to membrane binding and cofactor activity. Blood 2009; 114 (18):3938-3946. abstract

van den Biggelaar M, Meijer AB, Voorberg J, Mertens K. Intracellular co-trafficking of factor VIII and von Willebrand factor type 2N variants to storage organelles. Blood 2009; 113(13):3102-3109. abstract

Gouw SC, ter Avest PC, van Helden PM, Voorberg J, van den Berg HM. Discordant antibody response in monozygotic twins with severe haemophilia A caused by intensive treatment. Haemophilia 2009; 15(3):712-717. abstract

van den Heuvel E, De Laat B, Eckmann CM, Michiels JJ, Schneppenheim R, Budde U, van Mourik JA, Versteegh FG. A novel type 2A von Willebrand factor mutation (V1499E) associated with variable clinical expression. J Pediatr Hematol Oncol 2009; 31(4):277-280. abstract

van den Biggelaar M, Bouwens EA, Kootstra NA, Hebbel RP, Voorberg J, Mertens K. Storage and regulated secretion of factor VIII in blood outgrowth endothelial cells. Haematologica 2009; 94(5):670-678. abstract

van den Biggelaar M, Bouwens EA, Kootstra NA, Hebbel RP, Voorberg J, Mertens K. Storage and regulated secretion of factor VIII in blood outgrowth endothelial cells. Haematologica 2009; 94 (5):670-678. abstract

Larkin D, De Laat B, Jenkins PV, Bunn J, Craig AG, Terraube V, Preston RJ, Donkor C, Grau GE, van Mourik JA, O'Donnell JS. Severe Plasmodium falciparum malaria is associated with circulating ultra-large von Willebrand multimers and ADAMTS13 inhibition. PLoS Pathog 2009; 5(3):e1000349. abstract

van Helden PM, van den Berg HM, Gouw SC, Kaijen PH, Zuurveld MG, Mauser-Bunschoten EP, Aalberse RC, Vidarsson G, Voorberg J. Corrigendum to: IgG subclasses of anti-FVII antbodies during immune tolerance induction in patients with hemophilia - vol. 142 pg 644, 2008. Br J Haematol 2009; 144(4):625-625. abstract

De Laat B, Eckmann CM, van Schagen M, Meijer AB, Mertens K, van Mourik JA. Correlation between the potency of a beta2-glycoprotein I-dependent lupus anticoagulant and the level of resistance to activated protein C. Blood Coagul Fibrinolysis 2008; 19(8):757-764. abstract

Pos W, Luken BM, Kremer Hovinga JA, Turenhout EA, Scheiflinger F, Dong JF, Fijnheer R, Voorberg J. VH1-69 germline encoded antibodies directed towards ADAMTS13 in patients with acquired TTP. J Thromb Haemost 2009; 7(3):421-428. abstract

van den Biggelaar M. Factor VIII trafficking to Weibel-Palade bodies [De route van factor VIII naar Weibel-Palade bodies]. University of Utrecht, Utrecht, August 27, 2008;

Li Y, Choi H, Zhou Z, Nolasco L, Pownall HJ, Voorberg J, Moake JL, Dong JF. Covalent regulation of ULVWF string formation and elongation on endothelial cells under flow conditions. J Thromb Haemost 2008; 6(7):1135-1143. abstract

Li Y, Choi H, Zhou Z, Nolasco L, Pownall HJ, Voorberg J, Moake JL, Dong JF. Covalent regulation of ULVWF string formation and elongation on endothelial cells under flow conditions. J Thromb Haemost 2008; 6(1538-7836 (Electronic)):1135-1143. abstract

de Groot PG, Derksen RH, De Laat B. Twenty-two years of failure to set up undisputed assays to detect patients with the antiphospholipid syndrome. Semin Thromb Hemost 2008; 34(4):347-355. abstract

van Helden PM, van den Berg HM, Gouw SC, Kaijen PH, Zuurveld MG, Mauser-Bunschoten EP, Aalberse RC, Vidarsson G, Voorberg J. IgG subclasses of anti-FVIII antibodies during immune tolerance induction in patients with hemophilia A. Br J Haematol 2008; 1442(4):644-652. abstract

van Helden PM, van den Berg HM, Gouw SC, Kaijen PH, Zuurveld MG, Mauser-Bunschoten EP, Aalberse RC, Vidarsson G, Voorberg J. IgG subclasses of anti-FVIII antibodies during immune tolerance induction in patients with hemophilia A. Br J Haematol 2008; 1442 (4):644-652. abstract

Millar CM, Riddell AF, Brown SA, Starke R, Mackie I, Bowen DJ, Jenkins PV, van Mourik JA. Survival of von Willebrand factor released following DDAVP in a type 1 von Willebrand disease cohort: influence of glycosylation, proteolysis and gene mutations. Thromb Haemost 2008; 99(5):916-924. abstract

Rondaij MG, Bierings R, van Agtmaal EL, Gijzen KA, Sellink E, Kragt A, Ferguson SS, Mertens K, Hannah MJ, van Mourik JA, Fernandez-Borja M, Voorberg J. Guanine exchange factor RalGDS mediates exocytosis of Weibel-Palade bodies from endothelial cells. Blood 2008; 112(1):56-63. abstract

Rondaij MG, Bierings R, van Agtmaal EL, Gijzen KA, Sellink E, Kragt A, Ferguson SS, Mertens K, Hannah MJ, van Mourik JA, Fernandez-Borja M, Voorberg J. Guanine exchange factor RalGDS mediates exocytosis of Weibel-Palade bodies from endothelial cells. Blood 2008; 112 (1):56-63. abstract

Ananyeva NM, Makogonenko YM, Kouiavskaia DV, Ruiz J, Limburg V, Meijer AB, Khrenov AV, Shima M, Strickland DK, Saenko EL. The binding sites for the very low density lipoprotein receptor and low-density lipoprotein receptor-related protein are shared within coagulation factor VIII. Blood Coagul Fibrinolysis 2008; 19(2):166-177. abstract

De Laat B, Mertens K, de Groot PG. Mechanisms of Disease: antiphospholipid antibodies-from clinical association to pathologic mechanism. Nat Clin Pract Rheumatol 2008; 4(4):192-199. abstract

De Laat B, Mertens K, de Groot PG. Mechanisms of Disease: antiphospholipid antibodies-from clinical association to pathologic mechanism. Nat Clin Pract Rheumatol 2008; 4 (4):192-199. abstract

Bierings R, Beato M, Edel MJ. An endothelial cell genetic screen identifies the GTPase Rem2 as a suppressor of p19ARF expression that promotes endothelial cell proliferation and angiogenesis. J Biol Chem 2008; 283(7):4408-4416. abstract

van den Biggelaar M, Bierings R, Storm G, Voorberg J, Mertens K. Requirements for cellular co-trafficking of factor VIII and von Willebrand factor to Weibel-Palade bodies. J Thromb Haemost 2007; 5(11):2235-2243. abstract

van Helden PM, Kaijen PH, Fijnvandraat K, van den Berg HM, Voorberg J. Factor VIII-specific memory B cells in patients with hemophilia A. J Thromb Haemost 2007; 5(11):2306-2308. abstract

Bierings R. Sorting out the Weibel-Palade body. University Utrecht, Utrecht, October 17, 2007;

Bierings R, van den Biggelaar M, Kragt A, Mertens K, Voorberg J, van Mourik JA. Efficiency of von Willebrand factor-mediated targeting of IL-8 into Weibel-Palade bodies. J Thromb Haemost 2007; 5(12):2512-2519. abstract

Bierings R, van den Biggelaar M, Kragt A, Mertens K, Voorberg J, van Mourik JA. Efficiency of von Willebrand factor-mediated targeting of IL-8 into Weibel-Palade bodies. J Thromb Haemost 2007; 5 (12):2512-2519. abstract

Coppens M, van Mourik JA, Eckmann CM, Buller HR, Middeldorp S. Current practise of testing for inherited thrombophilia. J Throm Haemost 2007; 5(9):1979-1981. abstract

Hovinga JA, Zeerleder S, Kessler P, de Wit TR, van Mourik JA, Hack CE, ten Cate H, Reitsma PH, Wuillemin WA, Lammle B. ADAMTS-13, von Willebrand factor and related parameters in severe sepsis and septic shock. J Thromb Haemost 2007; 5(11):2284-2290. abstract

Hovinga JA, Zeerleder S, Kessler P, de Wit TR, van Mourik JA, Hack CE, ten Cate H, Reitsma PH, Wuillemin WA, Lammle B. ADAMTS-13, von Willebrand factor and related parameters in severe sepsis and septic shock. J Thromb Haemost 2007; 5 (11):2284-2290. abstract

Bierings R. Sorting out the Weibel-Palade body. University Utrecht, Utrecht, October 17, 2007;

Riksen NP, Luken BM, Klasen IS, Voorberg J, Crama N, van Deuren M. Antibodies against the CUB1-2 domains of ADAMTS13 in a patient with benign monoclonal gammopathy: no causal relationship. Haematologica 2007; 92(7):e74-e76. abstract

van Helden PMW. Immune Tolerance Induction in Hemophilia A = Immuuntolerantie inductie in hemofilie A. University Utrecht, Utrecht, July 3, 2007;

Eckmann CM, de Laaf RT, Van Keulen JM, van Mourik JA, De Laat B. Bilirubin oxidase as a solution for the interference of hyperbilirubinemia with ADAMTS-13 activity measurement by FRETS-VWF73 assay. J Thromb Haemost 2007; 5(6):1330-1331. abstract

Meijer AB, Rohlena J, van der Zwaan C, van Zonneveld AJ, Boertjes RC, Lenting PJ, Mertens K. Functional duplication of ligand-binding domains within low-density lipoprotein receptor-related protein for interaction with receptor associated protein, alpha(2)-macroglobulin, factor IXa and factor VIII. Biochim Biophys Acta 2007; 1774(6):714-722. abstract

Zhou C, Chen H, Lu F, Sellak H, Daigle JA, Alexeyev MF, Xi Y, Ju J, van Mourik JA, Wu S. Cav3.1 (alpha1G) controls von Willebrand factor secretion in rat pulmonary microvascular endothelial cells. Am J Physiol Lung Cell Mol Physiol 2007; 292(4):L833-L844. abstract

Rits MA, van Dort KA, Munk C, Meijer AB, Kootstra NA. Efficient Transduction of Simian Cells by HIV-1-based Lentiviral Vectors that Contain Mutations in the Capsid Protein. Mol Ther 2007; 15(5):930-937. abstract

Rits MA, van Dort KA, Munk C, Meijer AB, Kootstra NA. Efficient Transduction of Simian Cells by HIV-1-based Lentiviral Vectors that Contain Mutations in the Capsid Protein. Mol Ther 2007; 15 (5):930-937. abstract

Reipert BM, van Helden PM, Schwarz HP, Hausl C. Mechanisms of action of immune tolerance induction against factor VIII in patients with congenital haemophilia A and factor VIII inhibitors. Br J Haematol 2007; 136(1):12-25. abstract

Nathwani AC, Gray JT, Ng CY, Zhou J, Spence Y, Waddington SN, Tuddenham EG, Kemball-Cook G, McIntosh J, Boon-Spijker M, Mertens K, Davidoff AM. Self complementary adeno-associated virus vectors containing a novel liver-specific human factor IX expression cassette enable highly efficient transduction of murine and nonhuman primate liver. Blood 2006; 107 (7):2653-2661. abstract

Tjernberg P, Vos HL, Spaargaren-van Riel CC, Luken BM, Voorberg J, Bertina RM, Eikenboom JC. Differential effects of the loss of intrachain- versus interchain-disulfide bonds in the cystine-knot domain of von Willebrand factor on the clinical phenotype of von Willebrand disease. Thromb Haemost 2006; 96(6):717-724. abstract

Rondaij MG, Bierings R, Kragt A, Gijzen KA, Sellink E, van Mourik JA, Fernandez-Borja M, Voorberg J. Dynein-Dynactin Complex Mediates Protein Kinase A-Dependent Clustering of Weibel-Palade Bodies in Endothelial Cells. Arterioscler Thromb Vasc Biol 2006; 26(1):49-55. abstract

Nossent AY, van Marion V, van Tilburg NH, Rosendaal FR, Bertina RM, van Mourik JA, Eikenboom HC. Von Willebrand factor and its propeptide: the influence of secretion and clearance on protein levels and the risk of venous thrombosis. J Thromb Haemost 2006; 4 (12):2556-2562. abstract

Fribourg C, Meijer AB, Mertens K. The Interface between the EGF2 Domain and the Protease Domain in Blood Coagulation Factor IX Contributes to Factor VIII Binding and Factor X Activation. Biochemistry 2006; 45(35):10777-10785. abstract

Luken BM, Turenhout EA, Kaijen PH, Greuter MJ, Pos W, van Mourik JA, Fijnheer R, Voorberg J. Amino acid regions 572-579 and 657-666 of the spacer domain of ADAMTS13 provide a common antigenic core required for binding of antibodies in patients with acquired TTP. Thromb Haemost 2006; 96(3):295-301. abstract

Luken BM, Kaijen PH, Turenhout EA, Hovinga JA, van Mourik JA, Fijnheer R, Voorberg J. Multiple B-cell clones producing antibodies directed to the spacer and disintegrin/thrombospondin type-1 repeat 1 (TSP1) of ADAMTS13 in a patient with acquired thrombotic thrombocytopenic purpura. J Thromb Haemost 2006; 4(11):2355-2364. abstract

Bos MH. Regulatory mechanisms in the inactivation of blood coagulation factors V and VIII = Regulerende mechanismen in de inactivering van bloedstollingsfactoren V en VIII. Utrecht University, Utrecht, March 28, 2006;

Bovenschen N, van Stempvoort G, Voorberg J, Mertens K, Meijer AB. Proteolytic cleavage of factor VIII heavy chain is required to expose the binding-site for low-density lipoprotein receptor-related protein within the A2 domain. J Thromb Haemost 2006; 4(7):1487-1493. abstract

Bos MH. Regulatory mechanisms in the inactivation of blood coagulation factors V and VIII = Regulerende mechanismen in de inactivering van bloedstollingsfactoren V en VIII. Utrecht University, Utrecht, March 28, 2006;

Bouma BN, van Mourik JA. Unraveling the mystery of von Willebrand factor. J Thromb Haemost 2006; 4(3):489-495. abstract

Luken BM. Antibodies directed to ADAMTS13 in acquired thrombotic thrombocytopenic purpura = Antistoffen tegen ADAMTS13 in verworven trombotische trombocytopenische purpura. Utrecht University, Utrecht, January 30, 2006;

Rondaij MG. Regulation of Weibel-Palade body exocytosis in human endothelial cells = Regulatie van Weibel-Palade body exocytose in humane endotheelcellen. Utrecht University, Utrecht, January 16, 2006;

Rondaij MG, Bierings R, Kragt A, van Mourik JA, Voorberg J. Dynamics and Plasticity of Weibel-Palade Bodies in Endothelial Cells. Arterioscler Thromb Vasc Biol 2006; 26:1002-1007. abstract

Dekker RJ, Boon RA, Rondaij MG, Kragt A, Volger OL, Elderkamp YW, Meijers JC, Voorberg J, Pannekoek H, Horrevoets AJ. KLF2 provokes a gene expression pattern that establishes functional quiescent differentiation of the endothelium. Blood 2006; 107(11):4354-4363. abstract

Dekker RJ, Boon RA, Rondaij MG, Kragt A, Volger OL, Elderkamp YW, Meijers JC, Voorberg J, Pannekoek H, Horrevoets AJ. KLF2 provokes a gene expression pattern that establishes functional quiescent differentiation of the endothelium. Blood 2006; 107 (11):4354-4363. abstract

Bril WS, van Helden PM, Hausl C, Zuurveld MG, Ahmad RU, Hollestelle MJ, Reitsma PH, Fijnvandraat K, van Lier RA, Schwarz HP, Mertens K, Reipert BM, Voorberg J. Tolerance to factor VIII in a transgenic mouse expressing human factor VIII cDNA carrying an Arg(593) to Cys substitution. Thromb Haemost 2006; 95(2):341-347. abstract

Frijns CJ, Fijnheer R, Algra A, van Mourik JA, van Gijn J, Rinkel GJ. Early circulating levels of endothelial cell activation markers in aneurysmal subarachnoid haemorrhage: associations with cerebral ischaemic events and outcome. J Neurol Neurosurg Psychiatry 2006; 77(1):77-83. abstract

Brinkman HJ, Mertens K, van Mourik JA. Proteolytic cleavage of protein S during the hemostatic response. J Thromb Haemost 2005; 3(12):2712-2720. abstract

Nathwani AC, Gray JT, Ng CY, Zhou J, Spence Y, Waddington SN, Tuddenham EG, Kemball-Cook G, McIntosh J, Boon-Spijker M, Mertens K, Davidoff AM. Self complementary adeno-associated virus vectors containing a novel liver-specific human factor IX expression cassette enable highly efficient transduction of murine and nonhuman primate liver. Blood 2006; 107(7):2653-2661. abstract

Schooten CJ, Tjernberg P, Westein E, Terraube V, Castaman G, van Mourik JA, Hollestelle MJ, Vos HL, Bertina RM, Berg HM, Eikenboom JC, Lenting PJ, Denis CV. Cysteine-mutations in von Willebrand factor associated with increased clearance. J Thromb Haemost 2005; 3(10):2228-2237. abstract

Hollestelle MJ, Poyck PP, Hollestelle JM, Marsman HA, van Mourik JA, van Gulik TM. Extra-hepatic factor VIII expression in porcine fulminant hepatic failure. J Thromb Haemost 2005; 3:2274-2280. abstract

Hollestelle MJ, Poyck PP, Hollestelle JM, Marsman HA, van Mourik JA, van Gulik TM. Extra-hepatic factor VIII expression in porcine fulminant hepatic failure. J Thromb Haemost 2005; 3 :2274-2280. abstract

Autin L, Miteva MA, Lee WH, Mertens K, Radtke KP, Villoutreix BO. Molecular models of the procoagulant factor VIIIa-factor IXa complex. J Thromb Haemost 2005; 3(9):2044-2056. abstract

Onland W, Boing AN, Meijer AB, Schaap MC, Nieuwland R, Haasnoot K, Sturk A, Peters M. Congenital deficiency of factor XIII caused by two missense mutations in a Dutch family. Haemophilia 2005; 11(5):539-547. abstract

Brinkman HJM, van Mourik JA. Proteine S, een nog steeds onbegrepen rem van het stollingssysteem. Analyse 2005; (2):37-41.

Fribourg C. Catalytic Function of Blood Coagulation Factor IX. Utrecht University, Utrecht, October 28, 2005;

Bovenschen N, Rijken DC, Havekes LM, Vlijmen BJ, Mertens K. The B domain of coagulation factor VIII interacts with the asialoglycoprotein receptor. J Thromb Haemost 2005; 3(6):1257-1265. abstract

Espirito Santo SM, Rensen PC, Goudriaan JR, Bensadoun A, Bovenschen N, Voshol PJ, Havekes LM, van Vlijmen BJ. Triglyceride-rich lipoprotein metabolism in unique VLDL receptor, LDL receptor, and LRP triple-deficient mice. J Lipid Res 2005; 46(6):1097-1102. abstract

Brinkman HJM, van Mourik JA. Proteine S, een nog steeds onbegrepen rem van het stollingssysteem. Analyse 2005; (2):37-41.

Lewis DA, Bovenschen N, Mertens K, Voorberg J, Ortel TL. Phospholipid vesicles interfere with the binding of antibody fragments to the light chain of factor VIII. Thromb Haemost 2005; 93(5):833-841. abstract

Bovenschen N, Mertens K, Hu L, Havekes LM, van Vlijmen BJ. LDL receptor cooperates with LDL receptor-related protein in regulating plasma levels of coagulation factor VIII in vivo. Blood 2005; 106(3):906-912. abstract

Bovenschen N, Mertens K, Hu L, Havekes LM, van Vlijmen BJ. LDL receptor cooperates with LDL receptor-related protein in regulating plasma levels of coagulation factor VIII in vivo. Blood 2005; 106 (3):906-912. abstract

Bos MH, Meijerman DW, van der Zwaan C, Mertens K. Does activated protein C-resistant factor V contribute to thrombin generation in hemophilic plasma?. J Thromb Haemost 2005; 3(3):522-530. abstract

Fribourg C. Catalytic Function of Blood Coagulation Factor IX. Utrecht University, Utrecht, October 28, 2005;

Luken BM, Turenhout EA, Hulstein JJ, van Mourik JA, Fijnheer R, Voorberg J. The spacer domain of ADAMTS13 contains a major binding site for antibodies in patients with thrombotic thrombocytopenic purpura. Thromb Haemost 2005; 93(2):267-274. abstract

Mertens K. A factor VIII-polypeptide with factor VIII: C-activity. 2004;

Bovenschen N, Dijk KW, Havekes LM, Mertens K, Vlijmen BJ. Clearance of coagulation factor VIII in very low-density lipoprotein receptor knockout mice. Br J Haematol 2004; 126(5):722-725. abstract

van Helden PM, van den Berg HM, Gouw SC, Kaijen PH, Zuurveld MG, Mauser-Bunschoten EP, Aalberse RC, Vidarsson G, Voorberg J. Corrigendum to: IgG subclasses of anti-FVII antbodies during immune tolerance induction in patients with hemophilia - vol. 142 pg 644, 2008. Br J Haematol 2009; 144(4):625-625. abstract

Romani de Wit T, Rondaij MG, van Mourik JA. Weibel-Palade-lichaampjes: unieke secretieorganellen in endotheelcellen [Weibel-Palade bodies: unique secretory organelles within endothelial cells]. Ned Tijdschr Geneeskd 2004; 148(32):1572-1577. abstract

Brinkman HJM. Endothelial cells, their procoagulant side = Endotheelcellen, de procoagulante keerzijde. University of Utrecht, Utrecht, November 10, 2004;

Hollestelle MJ. Factor VIII expression and regulation in health and disease. University of Amsterdam, Amsterdam, December 17, 2004;

Rohlena J. Molecular Interactions between Coagulation Factor IX and Low Density Lipoprotein Receptor-related protein = Moleculaire interacties tussen stollingsfactor IX en LDL receptor-gerelateerde proteine. University of Utrecht, Utrecht, December 13, 2004;

Voorberg J, Bril WS, van den Brink EN. Analysis of factor VIII inhibitors using phage display. Haematologica 2004; 88(suppl. 12):18-25.

van Mourik JA. Van Creveld, pioneer of hemophilia care and coagulation research in the Netherlands: a personal account. J Thromb Haemost 2004; 2(7):1029-1033. abstract

Espirito Santo SM, Pires NM, Boesten LS, Gerritsen G, Bovenschen N, van Dijk KW, Jukema JW, Princen HM, Bensadoun A, Li WP, Herz J, Havekes LM, van Vlijmen BJ. Hepatic low-density lipoprotein receptor-related protein deficiency in mice increases atherosclerosis independent of plasma cholesterol. Blood 2004; 103(10):3777-3782. abstract

Rondaij MG, Sellink E, Gijzen KA, ten Klooster JP, Hordijk PL, van Mourik JA, Voorberg J. Small GTP-Binding Protein Ral Is Involved in cAMP-Mediated Release of von Willebrand Factor From Endothelial Cells. Arterioscler Thromb Vasc Biol 2004; 24(7):1315-1320. abstract

Hollestelle MJ, Geertzen HG, Straatsburg IH, van Gulik TM, van Mourik JA. Factor VIII expression in liver disease. Thromb Haemost 2004; 91(2):267-275. abstract

Stavenuiter F. Factor Seven Activating Protease: in Search of a Physiological Role. Utrecht, Utrecht University, June 23, 2010;

Romani de Wit T, Fijnheer R, Brinkman HJ, Kersting S, Hene RJ, van Mourik JA. Endothelial cell activation in thrombotic thrombocytopenic purpura (TTP): a prospective analysis. Br J Haematol 2003; 123(3):522-527. abstract

Schatz S, Turecek PL, Fiedler C, Zimmermann K, Gritsch H, Voorberg J, Schwarz HP, Dorner F, Scheiflinger F. Evaluation of the haemostatic potential of factor VIII-heparin cofactor II hybrid proteins in a mouse model. Br J Haematol 2003; 123(4):692-695. abstract

Echard A, Opdam FJ, de Leeuw HJ, Jollivet F, Savelkoul P, Hendriks W, Voorberg J, Goud B, Fransen JA. Alternative splicing of the human Rab6A gene generates two close but functionally different isoforms. Mol Biol Cell 2000; 11(11):3819-3833. abstract

Astermark J, Voorberg J, Lenk H, DiMichele D, Shapiro A, Tjonnfjord G, Berntorp E. Impact of inhibitor epitope profile on the neutralizing effect against plasma-derived and recombinant factor VIII concentrates in vitro. Haemophilia 2003; 9(5):567-572. abstract

Bos JC, Toorians AW, van Mourik JC, van Schijndel RJ. Emergency resection of an extra-adrenal phaeochromocytoma: wrong or right? A case report and a review of literature. Neth J Med 2003; 61(8):258-265. abstract

Romani de Wit T. Weibel-Palade bodies : an exciting way out! = Weibel-Palade lichaampjes : een prikkelende uitweg! (met een samenvatting in het Nederlands). University of Utrecht, Utrecht, February 20, 2003;

Bovenschen N, Herz J, Grimbergen JM, Lenting PJ, Havekes LM, Mertens K, van Vlijmen BJ. Elevated plasma factor VIII in a mouse model of low-density lipoprotein receptor-related protein deficiency. Blood 2003; 101(10):3933-3939. abstract

Romani de Wit T, de Leeuw HP, Rondaij MG, de Laaf RT, Sellink E, Brinkman HJ, Voorberg J, van Mourik JA. Von Willebrand factor targets IL-8 to Weibel-Palade bodies in an endothelial cell line. Exp Cell Res 2003; 286(1):67-74. abstract

Romani de Wit T, Rondaij MG, Hordijk PL, Voorberg J, van Mourik JA. Real-time imaging of the dynamics and secretory behavior of weibel-palade bodies. Arterioscler Thromb Vasc Biol 2003; 23(5):755-761. abstract

Bovenschen N, Boertjes RC, van Stempvoort G, Voorberg J, Lenting PJ, Meijer AB, Mertens K. Low density lipoprotein receptor-related protein and factor IXa share structural requirements for binding to the A3 domain of coagulation factor VIII. J Biol Chem 2003; 278(11):9370-9377. abstract

Rohlena J, Kolkman JA, Boertjes RC, Mertens K, Lenting PJ. Residues Phe342-Asn346 of activated coagulation factor IX contribute to the interaction with low density lipoprotein receptor-related protein. J Biol Chem 2003; 278(11):9394-9401. abstract

Fijnvandraat K, Bril WS, Voorberg J. Immunobiology of inhibitor development in hemophilia A. Semin Thromb Hemost 2003; 29(1):61-68. abstract

ten Cate H, Brandjes DP, Smits PH, van Mourik JA. The role of platelets in venous thrombosis: a patient with Glanzmann′s thrombasthenia and a factor V Leiden mutation suffering from deep venous thrombosis. J Thromb Haemost 2003; 1(2):394-395. abstract

Bril WS, Turenhout EA, Kaijen PH, van den Brink EN, Koopman MM, Peters M, Voorberg J. Analysis of factor VIII inhibitors in a haemophilia A patient with an Arg593-->Cys mutation using phage display. Br J Haematol 2002; 119(2):393-396. abstract

Vlot AJ, Wittebol S, Strengers PFW, Turenhout EAM, Voorberg J, van den Berg HM, Mauser-Bunschoten EP. Factor VIII inhibitor in a patient with mild haemophilia A and an Asn(618) -> Ser mutation responsive to immune tolerance induction and cyclophosphamide. Br J Haematol 2002; 117(1):136-140. abstract

Celie PH, van Stempvoort G, Fribourg C, Schurgers LJ, Lenting PJ, Mertens K. The connecting segment between both epidermal growth factor-like domains in blood coagulation factor IX contributes to stimulation by factor VIIIa and its isolated A2 domain. J Biol Chem 2002; 277(23):20214-20220. abstract

Barrowcliffe TW, Mertens K, Preston FE, Ingerslev J. Laboratory aspects of haemophilia therapy. Haemophilia 2002; 8(3):244-249. abstract

van den Brink EN, Bril WS, Turenhout EA, Zuurveld M, Bovenschen N, Peters M, Yee TT, Mertens K, Lewis DA, Ortel TL, Lollar P, Scandella D, Voorberg J. Two classes of germline genes both derived from the V(H)1 family direct the formation of human antibodies that recognize distinct antigenic sites in the C2 domain of factor VIII. Blood 2002; 99(8):2828-2834. abstract

Brinkman HJ, Mertens K, van Mourik JA. Phospholipid-binding domain of factor VIII is involved in endothelial cell-mediated activation of factor X by factor IXa. Arterioscler Thromb Vasc Biol 2002; 22(3):511-516. abstract

Stoilova-McPhie S, Villoutreix BO, Mertens K, Kemball-Cook G, Holzenburg A. 3-Dimensional structure of membrane-bound coagulation factor VIII: modeling of the factor VIII heterodimer within a 3-dimensional density map derived by electron crystallography. Blood 2002; 99(4):1215-1223. abstract

van Mourik JA, Romani de Wit T, Voorberg J. Biogenesis and exocytosis of Weibel-Palade bodies. Histochem Cell Biol 2002; 117(2):113-122. abstract

de Wit TR, van Mourik JA. Biosynthesis, processing and secretion of von Willebrand factor: biological implications. Best Pract Res Clin Haematol 2001; 14(2):241-255. abstract

Christophe OD, Lenting PJ, Cherel G, Boon-Spijker M, Lavergne JM, Boertjes R, Briquel ME, Goede-Bolder A, Goudemand J, Gaillard S, d' Oiron R, Meyer D, Mertens K. Functional mapping of anti-factor IX inhibitors developed in patients with severe hemophilia B. Blood 2001; 98(5):1416-1423. abstract

Hollestelle MJ, Thinnes T, Crain K, Stiko A, Kruijt JK, van Berkel TJC, Loskutoff DJ, van Mourik JA. Tissue distribution of factor VIII gene expression in vivo--a closer look. Thromb Haemost 2001; 86(3):855-861. abstract

van Mourik JA, Romani de Wit T. Von Willebrand factor propeptide in vascular disorders. Thromb Haemost 2001; 86(1):164-171. abstract

Rinke de Wit TF, Sanders EJ, Fontanet AL, Goudsmit J, Miedema F, Coutinho RA. Resultaten van het ′Ethiopia-Netherlands aids research project′; 1995-2000. Ned Tijdschr Geneeskd 2001; 145(26):1236-1240. abstract

de Leeuw HP, Fernandez-Borja M, Reits EA, Romani de Wit T, Wijers-Koster PM, Hordijk PL, Neefjes J, van Mourik JA, Voorberg J. Small GTP-binding protein Ral modulates regulated exocytosis of von Willebrand factor by endothelial cells. Arterioscler Thromb Vasc Biol 2001; 21(6):899-904. abstract

Mertens K. The future of plasma derivatives. Transfus Clin Biol 2001; 8(3):303-305. abstract

Romani de Wit T, van Mourik JA. Biosynthesis, processing and secretion of von Willebrand factor: biological implications. Best Pract Res Clin Haematol 2001; 14(2):241-255. abstract

van den Brink EN, Turenhout EA, Bovenschen N, Heijnen BG, Mertens K, Peters M, Voorberg J. Multiple VH genes are used to assemble human antibodies directed toward the A3-C1 domains of factor VIII. Blood 2001; 97(4):966-972. abstract

Folman CC, Linthorst GE, van Mourik J, van Willigen G, de Jonge E, Levi M, de Haas M, von dem Borne AEGK. Platelets release thrombopoietin (Tpo) upon activation: another regulatory loop in thrombocytopoiesis?. Thromb Haemost 2000; 83(6):923-930. abstract

van den Brink EN, Turenhout EA, Wijn-Maas EC, van der Meer FJ, Voorberg J, Bosch LJ. Disappearance of factor VIII autoantibodies preceding autoimmune haemolytic anaemia. Haemophilia 2000; 6(6):698-701. abstract

Voorberg J, van den Brink EN. Phage display technology: a tool to explore the diversity of inhibitors to blood coagulation factor VIII. Semin Thromb Hemost 2000; 26(2):143-150. abstract

Kolkman JA, Mertens K. Surface-loop residue Lys316 in blood coagulation Factor IX is a major determinant for Factor X but not antithrombin recognition. Biochem J 2000; 350 Pt 3:701-707. abstract

Celie PH. Molecular Sites in Blood Coagulation Factors VIII and IX Regulating Cofactor-Enzyme Interaction. University of Utrecht, Utrecht, May 3, 2000;

Folman CC, Linthorst GE, van Mourik J, van Willigen G, de Jonge E, Levi M, de Haas M, von dem Borne AEGK. Platelets release thrombopoietin (Tpo) upon activation: another regulatory loop in thrombocytopoiesis?. Thromb Haemost 2000; 83(6):923-930. abstract

Neels JG, Bovenschen N, van Zonneveld AJ, Lenting PJ. Interaction between factor VIII and LDL receptor-related protein - Modulation of coagulation?. Trends in Cardiovascular Medicine 2000; 10(1):8-14. abstract

Neels JG, van den Berg BMM, Mertens K, ter Maat H, Pannekoek H, van Zonneveld AJ, Lenting PJ. Activation of factor IX zymogen results in exposure of a binding site for low-density lipoprotein receptor-related protein. Blood 2000; 96(10):3459-3465. abstract

Schwarz HP, Lenting PJ, Binder B, Mihaly J, Denis C, Dorner F, Turecek PL. Involvement of low-density lipoprotein receptor-related protein (LRP) in the clearance of factor VIII in von Willebrand factor- deficient mice. Blood 2000; 95(5):1703-1708. abstract

Voorberg J, van den Brink EN. Phage display technology: a tool to explore the diversity of inhibitors to blood coagulation factor VIII. Semin Thromb Hemost 2000; 26(2):143-150. abstract

van den Brink EN, Turenhout EA, Bank CM, Fijnvandraat K, Peters M, Voorberg J. Molecular analysis of human anti-factor VIII antibodies by V gene phage display identifies a new epitope in the acidic region following the A2 domain. Blood 2000; 96(2):540-545. abstract

Hop C, Guilliatt A, Daly M, de Leeuw HP, Brinkman HJ, Peake IR, van Mourik JA, Pannekoek H. Assembly of multimeric von Willebrand factor directs sorting of P-selectin. Arterioscler Thromb Vasc Biol 2000; 20(7):1763-1768. abstract

Kolkman JA, Mertens K. Insertion loop 256-268 in coagulation factor IX restricts enzymatic activity in the absence but not in the presence of factor VIII. Biochemistry 2000; 39(25):7398-7405. abstract

Roelse JC, de Laaf RT, Timmermans SM, Peters M, van Mourik JA, Voorberg J. Intracellular accumulation of factor VIII induced by missense mutations Arg593-->Cys and Asn618-->Ser explains cross-reacting material-reduced haemophilia A. Br J Haematol 2000; 108(2):241-246. abstract

van den Brink EN, Turenhout EA, Davies J, Bovenschen N, Fijnvandraat K, Ouwehand WH, Peters M, Voorberg J. Human antibodies with specificity for the C2 domain of factor VIII are derived from VH1 germline genes. Blood 2000; 95(2):558-563. abstract

Celie PH, Lenting PJ, Mertens K. Hydrophobic contact between the two epidermal growth factor-like domains of blood coagulation factor IX contributes to enzymatic activity. J Biol Chem 2000; 275(1):229-234. abstract

De Laat B, Pengo V, Pabinger I, Musial J, Voskuyl AE, Bultink IE, Ruffatti A, Rozman B, Kveder T, de Moerloose P, Boehlen F, Rand J, Ulcova-Gallova Z, Mertens K, de Groot PG. The association between circulating antibodies against domain I of beta2-glycoprotein I and thrombosis: an international multicenter study. J Thromb Haemost 2009; 7(11):1767-1773. abstract

van Helden PM, van Haren SD, Fijnvandraat K, van den Berg HM, Voorberg J. Factor VIII-specific B cell responses in haemophilia A patients with inhibitors. Haemophilia 2010; 16(102):35-43. abstract

Pos W, Crawley JT, Fijnheer R, Voorberg J, Lane DA, Luken BM. An autoantibody epitope comprising residues R660, Y661 and Y665 in the ADAMTS13 spacer domain identifies a binding site for the A2 domain of VWF. Blood 2010; 115(8):1640-1649. abstract

Bril WS, MacLean PE, Kaijen PH, Brink EN, Lardy NM, Fijnvandraat K, Peters M, Voorberg J. HLA class II genotype and factor VIII inhibitors in mild haemophilia A patients with an Arg to Cys mutation. Haemophilia 2004; 10(5):509-514. abstract

van Helden PM, Kaijen PH, Mauser-Bunschoten EP, Fischer K, van den Berg HM, Voorberg J. Domain specificity of factor VIII inhibitors during immune tolerance induction in patients with haemophilia A. Haemophilia 2010; :epub. abstract

Barrowcliffe TW, Mertens K, Preston FE, Ingerslev J. Laboratory aspects of haemophilia therapy. Haemophilia 2002; 8(3):244-249. abstract

Celie PH, van Stempvoort G, Fribourg C, Schurgers LJ, Lenting PJ, Mertens K. The connecting segment between both epidermal growth factor-like domains in blood coagulation factor IX contributes to stimulation by factor VIIIa and its isolated A2 domain. J Biol Chem 2002; 277(23):20214-20220. abstract

van Mourik JA, Romani de Wit T. Von Willebrand factor propeptide in vascular disorders. Thromb Haemost 2001; 86(1):164-171. abstract

Bouma BN, van Mourik JA. Unraveling the mystery of von Willebrand factor. J Thromb Haemost 2006; 4(3):489-495. abstract

van den Brink EN, Turenhout EA, Wijn-Maas EC, van der Meer FJ, Voorberg J, Bosch LJ. Disappearance of factor VIII autoantibodies preceding autoimmune haemolytic anaemia. Haemophilia 2000; 6(6):698-701. abstract

Bridges DJ, Bunn J, van Mourik JA, Grau G, Preston RJ, Molyneux M, Combes V, O'Donnell JS, De Laat B, Craig A. Rapid activation of endothelial cells enables P. falciparum adhesion to platelet decorated von Willebrand factor strings. Blood 2010; 115(7):1472-1474. abstract

de Wit TR, van Mourik JA. Biosynthesis, processing and secretion of von Willebrand factor: biological implications. Best Pract Res Clin Haematol 2001; 14(2):241-255. abstract

Luken BM, Kaijen PH, Turenhout EA, Hovinga JA, van Mourik JA, Fijnheer R, Voorberg J. Multiple B-cell clones producing antibodies directed to the spacer and disintegrin/thrombospondin type-1 repeat 1 (TSP1) of ADAMTS13 in a patient with acquired thrombotic thrombocytopenic purpura. J Thromb Haemost 2006; 4 (11):2355-2364. abstract